International Science Community Association International Research Journal of Biological Sciences 14 3 2025 08 10 WUSCHEL: The master transcription factor in plant developmental biology 44 46 EN Mali Pinky J 1 Biology Department, B.K.M. Science College, Valsad, Gujarat, India and Biosciences Department, Veer Narmad South Gujarat University, Surat, Gujarat, India Patel Kalpesh 2 Biology Department, B.K.M. Science College, Valsad, Gujarat, India Nichat Avinash R. 1 Department of Zoology, M.M.V. P.G. College Bhakhara, Dhamtari, Chhattisgarh, India Nayak Jashavant 2 Department of Zoology, Govt. Dudhadhari Bajrang Girls Postgraduate College Raipur, Chhattisgarh, India Sori Premlal 3 Department of Botany, Govt. Mahaprabhu Vallabhacharya Postgraduate College Mahasamund, Chhattisgarh, India Warte Hitesh Kumar 4 Department of Zoology, Govt. Pt. Shyam Shankar Mishra College Deobhog, Gariyaband, Chhattisgarh, India Khiham J. 1 Department of Zoology, Dera Natung Government College, Itanagar, Arunachal Pradesh-791113, India Nanda P. 2 Department of Zoology, Dera Natung Government College, Itanagar, Arunachal Pradesh-791113, India Longkho K. 3 Department of Zoology, Dera Natung Government College, Itanagar, Arunachal Pradesh-791113, India Bo K. 4 Department of Zoology, Dera Natung Government College, Itanagar, Arunachal Pradesh-791113, India Chaudhariq Bhesh Raj 1 Department of Zoology, Mahendra Multiple Campus, Nepalgunj, Nepal Institute of Science and Technology, Tribhuvan University, Nepal Srivastava Deepa 1 Plant Pathology Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, India Tripathi Manisha 1 Department of Zoology, S.P.M. Govt. Degree College, University of Allahabad, Prayagraj -211013, India Agrawal Uma Rani 2 Department of Zoology, C.M.P. Degree College, University of Allahabad, Prayagraj, 211002, India Tripathi Jaya 3 Department of Zoology, Iswar Saran Degree College, University of Allahabad, Prayagraj - 211004, India Sultana Marufa 1 Charuchandra College, Kolkata-700029, India > Short Review Paper 2025 5 6 2025 08 10 Homeodomain transcription factors are proteins that bind to DNA by conserved HTH motif regions that controls and regulate expression of many target genes. WUSCHEL (WUS) and WUS-related home box (WOX) are the transcription factor controls shoot meristem activity through various signaling pathways. Another expression gene named CLV3 (CLAVATA) interacts with those homeo domain factors controls the meristems inside a plant. Current research has shown that there is a connection between WUS in the plant signaling pathways during genetic transformation, transition between vegetative structures to embryo formation, other aspect of plant development. In this review I give a detailed study of expression and activity of WUS and WOX gene. Copyright@ International Science Community Association