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Antimicrobial evaluations of propionic acid of quinazolines derivatives

Author Affiliations

  • 1Synthesis Organic and Medicinal Chemistry lab, Department of Chemistry, Mewar University, Gangrar, Rajasthan-312901, India
  • 2Synthesis Organic and Medicinal Chemistry lab, Department of Chemistry, Mewar University, Gangrar, Rajasthan-312901, India

Res.J.chem.sci., Volume 8, Issue (12), Pages 24-28, December,18 (2018)

Abstract

The derivatives of Propionic Acid of Quinazoline were synthesized. It was prepped by reaction of distinct amino acids with 7-nitro-2-phenyl-4H-benzo [1,3]oxazin-4-one. Configurations of same compounds have been appraised by NMR, MASS and IR spectral analysis. Synthesized compounds were screened with against following pathogenic bacteria Staphylococcus aureus, Staphylococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumonia. We used 500ppm concentration in DMSO for their antibacterial activity by Kirby-Baur disk diffusion method.

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