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A simple and convenient synthesis of α-cinnamic aryl-n-aryl nitrones [n-(3-phenylallylidene) aniline oxide] and their antibacterial activities

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Author Affiliations

  • 1PG and Research Department of Chemistry, Government Arts College for women, Nilakottai-624208, India
  • 2PG and Research Department of Chemistry, Government Arts College for women, Nilakottai-624208, India
  • 3PG and Research Department of Chemistry, Government Arts College for women, Nilakottai-624208, India
  • 4PG and Research Department of Chemistry, Government Arts College for women, Nilakottai-624208, India

Res.J.chem.sci., Volume 14, Issue (1), Pages 26-30, February,18 (2024)

Abstract

It is a popular two-step convenient method to prepare nitrones with distinctive phenylhydroxylamines and cinnamaldehydes. Nitrone is 1, 3-dipole and is one of the powerful substrate in 1,3-dipolar cycloadditions, it has drawn great attention because of its extensive tendency as a 1,3 dipole in Organic synthesis and its biological activities. Here the novel nitrones can be synthesized in exemplary yield (above 80%) and it has been confirmed by using 1H and 13C NMR techniques. The synthesized nitrone possess antibacterial activities in the bacterial strains of Pseudomonas aeruginosa, Bacillus marisflavi, Exiguobacterium Indicum and E.Coli.

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