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Development and validation method for the determination of atorvastatin calcium tablets drugs by using UV-spectrophotometer in pharmaceutical formulation

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Author Affiliations

  • 1Central laboratory, Shambat Campus, Khartoum University, Sudan
  • 2Lecturar at Chemistry Department, Faculty of science, Khartoum University, Sudan
  • 3Lecturar at Chemistry Department, Faculty of Pharmacy, Elrazi University, Sudan
  • 4Excellece Center of Pesticide and Environmental Science, Department of crop protection, Faculty of Agriculture, Khartoum University, Sudan
  • 5Central laboratory, Shambat Campus, Khartoum University, Sudan
  • 6Excellece Center of Pesticide and Environmental Science, Department of crop protection, Faculty of Agriculture, Khartoum University, Sudan

Res. J. of Pharmaceutical Sci., Volume 8, Issue (1), Pages 5-14, June,30 (2019)

Abstract

The objective of this research is to describe the optimization, validation, and application of spectrophotometric techniques for determination of Atorvastatin Calcium in their pharmaceutical formulation (tablets). In this paper simple, rapid, accurate and sensitive spectrophotometric methods have been developed and validated. This method is a direct spectrophotometric analytical method depend on dissolve of atorvastatin calcium in diluted anhydrous methanol methanol. The maximum absorption wavelength for determination of ATV drug was found to be 291 nanometer (nm), for Beer's law was obeyed in the concentration range from 5 to 35 µg/ml for UV- Spectrophotometric analysis method.

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